Ninja Blade plunges players into a gripping narrative where peacekeeping forces combat a parasitic threat that has unleashed carnivorous creatures upon the world. Set against a backdrop of chaos beginning on July 7th, 2011, in Northern Africa, the game unfolds as players uncover the reality of genetic mutations spurred by a newly discovered species of hookworm. These 'Alpha-worms' transform their hosts into formidable, ravenous adversaries. As outbreaks spread, elite forces are assembled to confront this escalating menace.

Players assume the role of a highly skilled ninja, equipped with three distinct weapons that allow for exhilarating and diverse combat. Engage in intense battles across the vibrant city of Tokyo, utilizing a rich array of powerful ninja abilities and a comprehensive weapon and ninjutsu upgrade system. The gameplay features cinematic action and quick-time events (QTEs) that enhance the experience, pushing players to master both strategy and reflexes during thrilling encounters.

With its combination of dynamic gunfights and fluid movement, Ninja Blade offers an adrenaline-fueled journey that redefines the action genre. Battle against overwhelming foes and confront the darkest aspects of this parasitic outbreak before it engulfs the world.